Throughout 2020, Metformin for type 2 diabetes has experienced multiple voluntary recalls from manufacturers. The latest involves two lots of extended-release formulas from Nostrum Laboratories. Testing indicates these products contain levels of nitrosamine N-Nitrosodimethylamine (NDMA) above the FDA’s Acceptable Daily Intake (ADI) limit of 96 ng/day.
Earlier this year, the FDA approved Invokana to reduce late-stage kidney disease and improve cardiovascular health in patients living with Type 2 diabetes and diabetic kidney disease. However, lawsuits dating back to 2015 indicate adverse cardiovascular events like heart attacks may be a side effect for certain patients.
In September 2019, Purdue Pharma reached an agreement to settle the large number of pending claims against their company. Purdue and its subsidiaries decided to file for Chapter 11 bankruptcy, which will help restructure the company, remove the company’s founding family and restrict where and how Purdue Pharma can do business moving forward.
The FDA has approved Invokana to reduce end-stage kidney disease, decreased kidney function, cardiovascular health and heart failure in adult patients living with Type 2 diabetes and diabetic kidney disease (nephropathy). Invokana is an SGLT2 inhibitor associated with amputation and diabetic ketoacidosis risks.
Hours before the first trial concerning the role of drug companies in the opioid epidemic, Teva Pharmaceuticals and three distributors settled for $260 million. Cuyahoga and Summit, two communities in Ohio, accused Teva – the world’s largest manufacturer of generic drugs – and distributors McKesson, Cardinal Health Inc. and AmerisourceBergen of making false, misleading claims that resulted in addiction and at least 400,000 fatalities.