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FDA isues asthma drug warnings

February 22nd, 2010

FDA urges restrictions on drugs that could make asthma suddenly worse: 2.18.2010

The FDA issued safety restrictions on Advair, Symibicort, Foradil, and Serevent saying these drugs should only be used by asthmatics who can’t control their lung disease with other medications.

Nor should these drugs ever be used without use of a different asthma-controlling medication, such as an inhaled corticosteroid.

The four drugs contain an ingredient that relaxes muscles around stressed airways, called a long-acting beta agonist or LABA. The way LABA-containing drugs work sometimes masks that inflammation is building in airways. That means patients may not realize that a serious asthma attack is brewing until they’re gasping for air.

The FDA is not pulling the drugs from the market because people with other lung diseases, such as COPD, use them without the asthma risk. They are taking a stronger step by labeling LABA-containing medications as contraindicated without simultaneous use of a different asthma-controlling medication.

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